I am a postdoctoral fellow at the University of Southern California, supported by the Croucher Foundation of Hong Kong . I work at the Center for New Technologies in Drug Discovery and Development and the Center for Advanced Research Computing . I am advised by Prof. Aiichiro Nakano and Prof. Vsevolod Katritch. I have extensive experience in Chemical Physics, Numerical Algorithms and Parallel Computing.
Most recent publications on Google Scholar. (The outbound hyperlinks for the papers/videos may take a little longer to redirect!)
‡ indicates equal contribution.
Scalable computation of anisotropic vibrations for large macromolecular assemblies
Lam JH, Nakano A, Katritch V
Nature Communications. 2024.
Nimrodd: Enhancing multi-resolution geometric neural hierarchy with an expectation maximization kernel
Lam JH, Sadybekov A, Ferrari T, Sadybekov A, Liu Y, Nakano A, Katritch V
In Preparation 2024
Structural insights into inverse agonism of an orphan receptor
Barekatain M‡, Johansson L‡, Lam JH‡, Chang H, Sadybekov A, Han GW, Russo J, Bliesath J, Brice N, Carlton M, Saikatendu K, Murphy S, Monenschein H, Schiffer H, Popov P, Lutomski C, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V
In Review 2024.
Structural details of a class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells
Aydin Y‡, Böttke T‡, Lam JH‡, Ernicke S, Fortmann A, Tretbar M, Zarzycka B, Gurevich VV, Katritch V, Coin I
Nature Communications 2023
A deep learning framework to predict binding preference of RNA constituents on protein surface
Lam JH, Li Y, Zhu L, Umarov R, Jiang H, Héliou A, Sheong FK, Liu T, Long Y, Li Y, Fang L, Altman RB, Chen W, Huang X, Gao X
Nature Communications 2019
Scalable computation of anisotropic vibrations for large macromolecular assemblies
Lam JH, Nakano A, Katritch V
Nature Communications. 2024.
Nimrodd: Enhancing multi-resolution geometric neural hierarchy with an expectation maximization kernel
Lam JH, Sadybekov A, Ferrari T, Sadybekov A, Liu Y, Nakano A, Katritch V
In Preparation 2024
Structural insights into inverse agonism of an orphan receptor
Barekatain M‡, Johansson L‡, Lam JH‡, Chang H, Sadybekov A, Han GW, Russo J, Bliesath J, Brice N, Carlton M, Saikatendu K, Murphy S, Monenschein H, Schiffer H, Popov P, Lutomski C, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V
In Review 2024.
Constitutive activation mechanism of a class C GPCR
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee J, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y
Nature Structural & Molecular Biology. 2024.
Structure of the dopamine D3 receptor bound to a bitopic agonist reveals a new specificity site in an expanded allosteric pocket
Arroyo-Urea S, Nazarova AL, Carrión-Antolí A, Bonifazi A, Battiti FO, Lam JH, Newman AH, Katritch V, García-Nafría J
Nature Communications. 2024. In Review.
Ligand and G-protein selectivity in the κ-opioid receptor
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature 2023
Structural details of a class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells
Aydin Y‡, Böttke T‡, Lam JH‡, Ernicke S, Fortmann A, Tretbar M, Zarzycka B, Gurevich VV, Katritch V, Coin I
Nature Communications 2023
Structural basis of GABA reuptake inhibition
Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C
Nature 2022
Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis
Zhang S, Yuan B, Lam JH, Zhou J, Zhou X, Ramos-Mandujano G, Tian X, Liu Y, Han R, Li Y, Gao X, Li M, Yang M
Cell Discovery 2021
Structural basis of the activation of a metabotropic GABA receptor
Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V
Nature 2020
Self-assembling tetrameric peptides allow in situ 3D bioprinting under physiological conditions
Rauf S, Susapto HH, Kahin K, Alshehri S, Abdelrahman S, Lam JH, Asad S, Jadhav S, Sundaramurthi D, Gao X, Hauser CAE
Journal of Materials Chemistry B 2019
A deep learning framework to predict binding preference of RNA constituents on protein surface
Lam JH, Li Y, Zhu L, Umarov R, Jiang H, Héliou A, Sheong FK, Liu T, Long Y, Li Y, Fang L, Altman RB, Chen W, Huang X, Gao X
Nature Communications 2019
Full Resume (likely not the most updated!) in PDF.
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